Hugs 98 source trial#
Hugs 98 source license#

ResultsĪ total of 635 children were fully enrolled 606 children completed screening and began receiving hydroxyurea at a mean (±SD) dose of 17.5☑.8 mg per kilogram per day. The end points assessed feasibility (enrollment, retention, and adherence), safety (dose levels, toxic effects, and malaria), and benefits (laboratory variables, sickle cell–related events, transfusions, and survival). Children received hydroxyurea at a dose of 15 to 20 mg per kilogram of body weight per day for 6 months, followed by dose escalation. We enrolled children 1 to 10 years of age with sickle cell anemia in four sub-Saharan countries. Coexisting conditions such as malnutrition and malaria may affect the feasibility, safety, and benefits of hydroxyurea in low-resource settings. Hydroxyurea is an effective treatment for sickle cell anemia, but few studies have been conducted in sub-Saharan Africa, where the burden is greatest. The most trusted, influential source of new medical knowledge and clinical best practices in the world.

Hugs 98 source license#

Information and tools for librarians about site license offerings. Valuable tools for building a rewarding career in health care. The authorized source of trusted medical research and education for the Chinese-language medical community.

The most advanced way to teach, practice, and assess clinical reasoning skills. Information, resources, and support needed to approach rotations - and life as a resident. The most effective and engaging way for clinicians to learn, improve their practice, and prepare for board exams. NEW! Peer-reviewed journal featuring in-depth articles to accelerate the transformation of health care delivery.Ĭoncise summaries and expert physician commentary that busy clinicians need to enhance patient care.

Hugs 98 source trial#

Camins said, “We’re not there yet.NEW! A digital journal for innovative original research and fresh, bold ideas in clinical trial design and clinical decision-making. If the virus keeps spreading unchecked, it could eventually spill over to a broader population, increasing everyone’s chances of an infection. But experts caution that this guidance could change as researchers gather more data on monkeypox. For example, sitting on a subway, bus or other public transportation or going to an office or school are unlikely to put people at risk of a monkeypox exposure. For those who are really nervous, she suggested just putting a new item in the laundry when they get home for some peace of mind.Īdditionally, some activities that people learned to limit during Covid-19 surges are probably not as risky for monkeypox transmission. “Personally, I’m less concerned with trying clothing on in the store,” she said. People are unlikely to get the virus by trying on clothing in a store or touching nonporous items like door handles and counters, Dr. Raves where people are having direct, skin-to-skin contact, dancing together for a longer duration of time may be riskier still, Dr. Attending a packed indoor party could put you at risk of getting the virus, particularly in parts of the country where cases are high. Still, just as with Covid-19, masking up indoors is a good idea if you want to protect yourself from monkeypox. Health officials recommend maintaining at least 6 feet of distance from unmasked patients to avoid getting exposed, although some experts argue that this number is arbitrary.

When it comes to respiratory droplet transmission, face-to-face or almost face-to-face contact is riskier than being several feet away. Shared utensils that may carry an infected person’s saliva should also be considered high risk, said Saskia Popescu, an infectious disease epidemiologist at George Mason University. Household contacts can catch monkeypox through contaminated clothes, towels and bedding. Condoms probably add a layer of protection during sex, but they are unlikely to prevent contact with lesions on an infected person’s groin, thighs, buttocks or on other parts of their body. This includes the kind of skin-to-skin contact that occurs during sex, as well as when cuddling, hugging, massaging or kissing another person. The activities that put a person at highest risk of catching the virus involve close, intimate contact with another infected individual. Here is how experts are thinking about everyday interactions, how the virus is transmitted during them and which behaviors carry the most risk. Jay Varma, a physician and epidemiologist who specializes in infectious diseases at Weill Cornell Medical School in New York City. How close you are to someone who is sick, how infectious they are, how much time you spend in their vicinity and your own personal health may affect your susceptibility, said Dr. Several factors can determine your risk of getting monkeypox, whether from caring for someone who is ill to attending packed parties or simply having sex.